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PROteolysisTArgeting嵌合体(PROTACs)分子是非常有前景的新药开发模式。

PROTAC可以通过诱导目标蛋白的降解来调节蛋白水平,在新作用机制干预方面,比如核酸疗法,修饰的多肽,重组蛋白和单克隆抗体等提供助力。

 

产品线图片来源:DOI:10.1021/acs.jcim.8b00872

 
产品编号 结构式 项目名称规格 分子式 加入购物车
A889152 5-氨基-2-(2,6-二氧代哌啶-3-基)异二氢吲哚-1,3-二酮, 95%
5-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione, 95%
C13H11N3O4
B889153 5-溴-2-(2,6-二氧哌啶-3-基)异吲哚啉-1,3-二酮, 95%
5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione, 95%
C13H9BrN2O4
B902516 3-(7-溴-1-氧亚基-2,3-二氢-1H-异吲哚-2-基)哌啶-2,6-二酮, 99%
3-(7-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione, 99%
C13H11BrN2O3
B902517 3-(4-溴-1-氧代异吲哚啉-2-基)哌啶-2,6-二酮, 98%
3-(4-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione, 98%
C13H11BrN2O3
D889143 2-(2,6-二氧代哌啶-3-基)-5-硝基异吲哚-1,3-二酮, 95%
2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline-1,3-dione, 95%
C13H9N3O6
D889144 2-(2,6-二氧代-哌啶-3-基)-4-氟基-异吲哚-1,3-二酮, 95%
2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione, 95%
C13H9FN2O4
D889155 2-(2,6-二氧代 - 哌啶-3-基)-4-羟基 - 异吲哚-1,3-二酮, 95%
2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione, 95%
C13H10N2O5
H902827 3-(4-羟基-1-氧代-1,3-二氢异吲哚-2-基)哌啶-2,6-二酮, 98%
3-(4-hydroxy-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione, 98%
C13H12N2O4
M889138 4-(2-羟乙基)苯甲酸甲酯, 98%
methyl 4-(2-hydroxyethyl)benzoate, 98%
C10H12O3
M902583 4-(4-叠氮基丁基)苯甲酸甲酯, 99%
methyl 4-(4-azidobutyl)benzoate, 99%
C12H15N3O2
N889139 5-氯-N-(2-(2,6-二氧代哌啶-3-基)-1,3-二氧异吲哚-4-基)戊酰胺, 95%
5-chloro-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)pentanamide, 95%
C18H18ClN3O5
N889154 2-氯-N-(2-(2,6-二氧代哌啶-3-基)-1,3-二氧异吲哚-4-基-乙酰胺, 95%
2-chloro-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide, 95%
C15H12ClN3O5
N889156 4-氯-N-(2-(2,6-二氧杂哌啶-3-基)-1,3-二氧异吲哚-4-基)丁酰胺, 95%
4-chloro-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)butanamide, 95%
C17H16ClN3O5
N889157 4-氯-N-(2-(2,6-二氧代哌啶-3-基)-1,3-二氧异吲哚-5-基)丁酰胺, 90%
4-chloro-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)butanamide, 90%
C17H16ClN3O5
N903476 3-氯-N-(2-(2,6-二氧代哌啶-3-基)-1,3-二氧异吲哚-4-基)丙酰胺, 90%
3-chloro-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)propanamide, 90%
C16H14ClN3O5
T889137 2-(2-(苄氧基)乙氧基)乙酸叔丁酯, 90%
tert-butyl 2-(2-(benzyloxy)ethoxy)acetate, 90%
C15H22O4
T902580 3-(4-((叔丁基二甲基甲硅烷基)氧基)-1-氧代异吲哚-2-基)哌啶-2,6-二酮, 98%
3-(4-((tert-butyldimethylsilyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione, 98%
C19H26N2O4Si
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